Periodical
A Phase 1, Randomized, Single-Ascending-Dose Study To Investigate the Safety, Tolerability, and Pharmacokinetics of DSTA4637S, an Anti-Staphylococcus aureusThiomab Antibody-Antibiotic Conjugate, in Healthy Volunteers
| العنوان: | A Phase 1, Randomized, Single-Ascending-Dose Study To Investigate the Safety, Tolerability, and Pharmacokinetics of DSTA4637S, an Anti-Staphylococcus aureusThiomab Antibody-Antibiotic Conjugate, in Healthy Volunteers |
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| المؤلفون: | Peck, Melicent, Rothenberg, Michael E., Deng, Rong, Lewin-Koh, Nicholas, She, Gaohong, Kamath, Amrita V., Carrasco-Triguero, Montserrat, Saad, Ola, Castro, Aide, Teufel, Lisa, Dickerson, Daniel S., Leonardelli, Marisa, Tavel, Jorge A. |
| المصدر: | Antimicrobial Agents and Chemotherapy; April 2019, Vol. 63 Issue: 6 |
| مستخلص: | Staphylococcus aureuscauses serious bacterial infections with high morbidity and mortality, necessitating the discovery of new antibiotics. DSTA4637S is a novel antibody-antibiotic conjugate designed to target intracellular S. aureusthat is not adequately eliminated by current standard-of-care antibiotics. |
| قاعدة البيانات: | Supplemental Index |
Full Text Finder | تدمد: | 00664804 10986596 |
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| DOI: | 10.1128/AAC.02588-18 |