Withanolides from Aeroponically Grown Physalis peruvianaand Their Selective Cytotoxicity to Prostate Cancer and Renal Carcinoma Cells

التفاصيل البيبلوغرافية
العنوان:	Withanolides from Aeroponically Grown Physalis peruvianaand Their Selective Cytotoxicity to Prostate Cancer and Renal Carcinoma Cells
المؤلفون:	Xu, Ya-Ming, Wijeratne, E. M. Kithsiri, Babyak, Ashley L., Marks, Hanna R., Brooks, Alan D., Tewary, Poonam, Xuan, Li-Jiang, Wang, Wen-Qiong, Sayers, Thomas J., Gunatilaka, A. A. Leslie
المصدر:	Journal of Natural Products; July 2017, Vol. 80 Issue: 7 p1981-1991, 11p
مستخلص:	Investigation of aeroponically grown Physalis peruvianaresulted in the isolation of 11 new withanolides, including perulactones I–L (1–4), 17-deoxy-23β-hydroxywithanolide E (5), 23β-hydroxywithanolide E (6), 4-deoxyphyperunolide A (7), 7β-hydroxywithanolide F (8), 7β-hydroxy-17-epi-withanolide K (9), 24,25-dihydro-23β,28-dihydroxywithanolide G (10), and 24,25-dihydrowithanolide E (11), together with 14 known withanolides (12–25). The structures of 1–11were elucidated by the analysis of their spectroscopic data, and 12–25were identified by comparison of their spectroscopic data with those reported. All withanolides were evaluated for their cytotoxic activity against a panel of tumor cell lines including LNCaP (androgen-sensitive human prostate adenocarcinoma), 22Rv1 (androgen-resistant human prostate adenocarcinoma), ACHN (human renal adenocarcinoma), M14 (human melanoma), SK-MEL-28 (human melanoma), and normal human foreskin fibroblast cells. Of these, the 17β-hydroxywithanolides (17-BHWs) 6, 8, 9, 11–13, 15, and 19–22showed selective cytotoxic activity against the two prostate cancer cell lines LNCaP and 22Rv1, whereas 13and 20exhibited selective toxicity for the ACHN renal carcinoma cell line. These cytotoxicity data provide additional structure–activity relationship information for the 17-BHWs.
قاعدة البيانات:	Supplemental Index

الوصف
تدمد:	01633864 15206025
DOI:	10.1021/acs.jnatprod.6b01129