Periodical
PIK3CAmutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation
| العنوان: | PIK3CAmutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation |
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| المؤلفون: | Anderson, Gray R., Wardell, Suzanne E., Cakir, Merve, Crawford, Lorin, Leeds, Jim C., Nussbaum, Daniel P., Shankar, Pallavi S., Soderquist, Ryan S., Stein, Elizabeth M., Tingley, Jennifer P., Winter, Peter S., Zieser-Misenheimer, Elizabeth K., Alley, Holly M., Yllanes, Alexander, Haney, Victoria, Blackwell, Kimberly L., McCall, Shannon J., McDonnell, Donald P., Wood, Kris C. |
| المصدر: | Science Translational Medicine; December 2016, Vol. 8 Issue: 369 p369ra175-369ra175, 1p |
| مستخلص: | Inhibitors of BCL-XL, combined with inhibition of the mTOR/4E-BP axis, drive regressions of PIK3CAmutant breast tumors. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 19466234 19466242 |
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| DOI: | 10.1126/scitranslmed.aae0348 |