Periodical
Adenosine A2Aand A2BReceptors Differentially Modulate Keratinocyte Proliferation: Possible Deregulation in Psoriatic Epidermis
| العنوان: | Adenosine A2Aand A2BReceptors Differentially Modulate Keratinocyte Proliferation: Possible Deregulation in Psoriatic Epidermis |
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| المؤلفون: | Andrés, Rosa M., Terencio, María Carmen, Arasa, Jorge, Payá, Miguel, Valcuende-Cavero, Francisca, Navalón, Pedro, Montesinos, María Carmen |
| المصدر: | Journal of Investigative Dermatology; January 2017, Vol. 137 Issue: 1 p123-131, 9p |
| مستخلص: | Adenosine is a potent regulator of inflammation and immunity, but the role of adenosine receptors in keratinocytes remains controversial. We determined that in addition to A2Breceptors, human epidermal keratinocytes also express A2Areceptors, although to a lower extent. Through the use of selective adenosine receptor agonists and antagonists, we showed that physiological concentrations of adenosine activate A2Breceptors in normal human keratinocytes, inducing cell cycle arrest through the increase of intracellular calcium but not through cAMP signaling. In contrast, the selective activation of A2Areceptors by CGS-21680 induces keratinocyte proliferation via p38–mitogen-activated protein kinase activation. Adenosine and selective A2Aand A2Bagonists presented anti-inflammatory profiles independent of adenosine receptors but mediated by membrane phosphatase activation. Finally, keratinocyte exposure to diverse inflammatory cytokines altered adenosine receptor expression by reducing A2Band increasing A2A, a pattern also observed in psoriatic epidermis. Because increased epidermal turnover and inflammatory response are characteristics of psoriatic disease, further studies are needed to assess the role and consequences of the altered adenosine receptor expression in lesional and nonlesional psoriatic keratinocytes. |
| قاعدة البيانات: | Supplemental Index |
Full Text Finder | تدمد: | 0022202X 15231747 |
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| DOI: | 10.1016/j.jid.2016.07.028 |