Periodical
ZO-2 silencing induces renal hypertrophy through a cell cycle mechanism and the activation of YAP and the mTOR pathway
| العنوان: | ZO-2 silencing induces renal hypertrophy through a cell cycle mechanism and the activation of YAP and the mTOR pathway |
|---|---|
| المؤلفون: | Domínguez-Calderón, Alaide, Ávila-Flores, Antonia, Ponce, Arturo, López-Bayghen, Esther, Calderón-Salinas, José-Víctor, Luis Reyes, José, Chávez-Munguía, Bibiana, Segovia, José, Angulo, Carla, Ramírez, Leticia, Gallego-Gutiérrez, Helios, Alarcón, Lourdes, Martín-Tapia, Dolores, Bautista-García, Pablo, González-Mariscal, Lorenza |
| المصدر: | Molecular Biology of the Cell; May 2016, Vol. 27 Issue: 10 p1581-1595, 15p |
| مستخلص: | The absence of ZO-2 promotes an increase in cell size by two mechanisms: an increase in cyclin D, which extends the time that the cells spend in the G1 phase of the cell cycle, and an accumulation of YAP at the nucleus, which promotes its transcriptional activity, triggering the activation of the mTORC1 complex and its target, S6K1. |
| قاعدة البيانات: | Supplemental Index |
Full Text Finder | تدمد: | 10591524 19394586 |
|---|---|
| DOI: | 10.1091/mbc.E15-08-0598 |