Constituents of the Twigs of Hernandia ovigera that Inhibit the Transformation of JB6 Murine Epidermal Cells

التفاصيل البيبلوغرافية
العنوان:	Constituents of the Twigs of Hernandia ovigera that Inhibit the Transformation of JB6 Murine Epidermal Cells
المؤلفون:	Gu, J.-Q., Park, E. J., Totura, S., Riswan, S., Fong, H. H. S., Pezzuto, J. M., Kinghorn, A. D.
المصدر:	Journal of Natural Products; July 2002, Vol. 65 Issue: 7 p1065-1068, 4p
مستخلص:	Activity-guided fractionation of an ethyl acetate extract of the twigs of Hernandia ovigera, using a soft agar assay with JB6 murine epidermal cells, led to the isolation of two new naturally occurring aryltetralin lignans, (7R,8S,7R,8R)-(+)-7-acetyl-5-methoxypicropodophyllin (1) and (7R,8S,7R,8R)-(+)-7-acetylpicropodophyllin (2), of which 2 was previously identified as a synthetic product, along with eight known compounds, epiyangambin (3), caruilignan C, diasesartemin, (+)-epimagnolin A, N-methylcorydaldine, (−)-5-methoxyyatein, (+)-syringaresinol dimethyl ether, and (−)-yatein. The structures and stereochemistry of 1 and 2 were determined using spectroscopic methods. Compounds 2 and 3 exhibited significant inhibition of the transformation of murine epidermal JB6 cells, with IC50 values of 0.15 and 0.4 μg/mL, respectively, while the other isolates were regarded as inactive (IC50 >4 μg/mL).
قاعدة البيانات:	Supplemental Index

الوصف
تدمد:	01633864 15206025
DOI:	10.1021/np020042w