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Differences in responses to propofol in elderly and young adult WISW rats

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العنوان: Differences in responses to propofol in elderly and young adult WISW rats
المؤلفون: Dirksen, Ris, Rijn, Clementina M. van, Egmond, Jan van, Luijtelaar, Gilles van
المصدر: Neuroscience Research Communications; September/October 1997, Vol. 21 Issue: 2 p125-134, 10p
مستخلص: How elderly and young adults differ in their susceptibility to propofol, a GABA-mimetic drug, was studied in WISW rats. The incidence of narcosis (4–20 mg/kg) or in the potency of propofol to inhibit withdrawal reflexes (ED50: 1.2 mg/kg) did not differ, but narcosis lasted longer (20 mg/kg: 25 min v. 17 min), and both the onset (t1/2: 0.7 min v. 0.3 min) and decay (t1/2: 16 min v. 7 min) of reflex inhibition were slower in elderly than in young adults. Moreover, propofol-induced behavior differed: tail flicks, head and body shakes and walking difficulties occurred less frequently, whereas vacuous chewing occurred more often in elderly than in young adult rats. In all, age-dependent difference in the potency of propofol show in susceptibility for certain side-effects and these may relate to rapidity of effect and GABA functionality in the brain. © 1997 John Wiley & Sons, Ltd.
قاعدة البيانات: Supplemental Index
الوصف
تدمد:08936609
15206769
DOI:10.1002/(SICI)1520-6769(199709/10)21:2<125::AID-NRC216>3.0.CO;2-T