Periodical
Correlation between Profile of Circulating Mononuclear Cells and Clinical Manifestations in Patients with Pemphigus Vulgaris
| العنوان: | Correlation between Profile of Circulating Mononuclear Cells and Clinical Manifestations in Patients with Pemphigus Vulgaris |
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| المؤلفون: | Gonzalez, Alvaro, Espaa, AgustIN, Lopez-Zabalza, MarIA, Pelacho, Beatriz, Sanchez-Carpintero, Ignacio, Santiago, Esteban, LOpez-Moratalla, Natalia |
| المصدر: | Autoimmunity; September 2000, Vol. 32 Issue: 2 p115-128, 14p |
| مستخلص: | Phenotypes of 38 samples of mononuclear (PBMC) cells from 11 different patients with pemphigus vulgaris (PV) at different stages of the disease were explored looking for a possible relationship between cell immunity, mucocutaneous or mucosal lesion intensity and capacity of serum autoantibodies to elicit the disease in mice. PBMC from 5 patients with mucocutaneous lesions and sera with IgG capable of inducing the disease in neonatal mice had a high proportion of mature monocytes with CD14lowDR gh and co-expresing CD16 and CDllb. In addition, a high proportion of CD19+CD5+ activated B cells and a very low proportion of naive CD4+CD45RA+ and CD8+CDllb+ T lymphocytes was observed. Monocytes from these patients expressed inducible nitric oxide synthase (iNOS). In contrast, PBMC from 6 patients, with lesions restricted to mucosal membranes and IgG lacking the capacity to induce the disease in mice, contained a high proportion of CD14hlg DRlow co-expressing CD16 circulating macrophages, CD8+CDllb+ T cells, and a low proportion of activated B lymphocytes. The results suggest a possible association between proportion of different antigen presenting cells (monocytes with high HLA-DR and low CD 14 expression and activated B lymphocytes, or differentiated monocytes/macrophages), type of PV and capacity of serum autoantibodies to elicit the disease in mice |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 08916934 1607842X |
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| DOI: | 10.3109/08916930008994081 |