Periodical
Action of tetanus toxin and colchicine on synaptic membranes of the rat cerebral cortex
| العنوان: | Action of tetanus toxin and colchicine on synaptic membranes of the rat cerebral cortex |
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| المؤلفون: | Kryzhanovskii, G. N., Sandalov, Yu. G., Rodina, V. I., Rozhanets, V. V., Glebov, R. N. |
| المصدر: | Bulletin of Experimental Biology and Medicine; February 1977, Vol. 83 Issue: 2 p129-132, 4p |
| مستخلص: | Purified tetanus toxin (TT), in experiments in vitro, was shown to affect neither the Na,K-ATPase activity of the synaptic membrane fraction of the rat cerebral cortex nor the inhibition of Na,K-ATPase activity produced by electrical stimulation of a suspension of synaptic membranes, nor the binding of GABA-3H by synaptosomes. TT and colchicine (1 mM) reduced the osmotic sensitivity of the nerve endings. Colchicine, in low concentrations (10-5 to 10-3 M), does not affect Mg- and Na,K-ATPase but, in higher concentrations (10-2 M), it inhibits the activity of both ATPases considerably. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 00074888 15738221 |
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| DOI: | 10.1007/BF00799399 |