التفاصيل البيبلوغرافية
| العنوان: |
Resorption, Verteilung und Galle-Ausscheidung einiger3H-markierter Derivate des Helveticosols |
| المؤلفون: |
Zielske, F., Voigtländer, W., Schaumann, W. |
| المصدر: |
Naunyn-Schmiedeberg's Archives of Pharmacology; February 1969, Vol. 265 Issue: 1 p49-66, 18p |
| مستخلص: |
Summary Helveticosol (strophanthidol-monodigitoxoside) and some of its esters and ethers were labelled with tritium by reduction of the C19-aldehyde group of helveticoside and the corresponding derivatives. Investigations on absorption, distribution and excretion in anaesthetized guinea-pigs gave the following results:1.Absorption was calculated from the percentage of the injected radioactivity which disappeared within two hours from an intestinal loop. With helveticosol as well as its mono- and dimethylether, there was a good agreement between this estunate of absorption and that derived from the relation of equiactive doses on intravenous and intraduodenal application. The absorption of diacetyl- and dipropionyl-helveticosol was less than expected from their activity on enterai application. This was explained by hydrolysis into more active metabolites.2.The distribution volume, calculated from the content of the body and the blood level, was lower after intraduodenal than after intravenous application. This was difficult to explain since there was no difference in the distribution coefficients of liver and heart and between the metabolites found in the blood after intravenous infusion or intraduodenal injection. There was no significant difference between the distribution volume after intraportal and intravenous infusion of monomethyl-helveticosol.3.Biliary excretion was measured after intravenous and intraduodenal administration and correlated with the mean blood and tissue levels. The glycosides which were best absorbed from the intestine were excreted most rapidly in the bile. |
| قاعدة البيانات: |
Supplemental Index |