Periodical
Autosomal dominant cyclic hematopoiesis: exclusion of linkage to the major hematopoietic regulatory gene cluster on chromosome 5
| العنوان: | Autosomal dominant cyclic hematopoiesis: exclusion of linkage to the major hematopoietic regulatory gene cluster on chromosome 5 |
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| المؤلفون: | Palmer, Susan E., Dale, David C., Livingston, Robert J., Wijsman, Ellen M., Stephens, Karen |
| المصدر: | Human Genetics; February 1994, Vol. 93 Issue: 2 p195-197, 3p |
| مستخلص: | Autosomal dominant cyclic hematopoiesis (ADCH), or cyclic neutropenia, is a genetic disorder characterized by cyclic oscillations of neutrophils and other blood cells. To determine if the gene for ADCH mapped within the major hematopoietic regulatory gene cluster at 5q23.3–q33.3, we tested five families with ADCH for genetic linkage between the disorder and loci on chromosome 5q. Two-point analyses gave significant evidence in favor of excluding linkage between ADCH and the hematopoietic genes granulocyte-macrophage colony-stimulating factor (CSF), interleukins 3, 4, 5, and 9, and the receptor of macrophage-CSF. Furthermore, the exclusion data provide evidence for rejecting the hypothesis that ADCH may be encoded by a new gene mapping within this cluster. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 03406717 14321203 |
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| DOI: | 10.1007/BF00210609 |