Periodical
Interactions of decapentaplegic, wingless, and Distal-lessin the Drosophilaleg
| العنوان: | Interactions of decapentaplegic, wingless, and Distal-lessin the Drosophilaleg |
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| المؤلفون: | Held, Lewis I., Heup, Michael A., Sappington, J. Mark, Peters, Scott D. |
| المصدر: | Development Genes and Evolution; May 1994, Vol. 203 Issue: 6 p310-319, 10p |
| مستخلص: | The genes decapentaplegic, wingless, and Distallessappear to be instrumental in constructing the anatomy of the adult Drosophilaleg. In order to investigate how these genes function and whether they act coordinately, we analyzed the leg phenotypes of the single mutants and their inter se double mutant compounds. In decapentaplegicthe tarsi frequently exhibit dorsal deficiencies which suggest that the focus of gene action may reside dorsally rather than distally. In winglessthe tarsal hinges are typically duplicated along with other dorsal structures, confirming that the hinges arise dorsally. The plane of symmetry in double-ventral duplications caused by decapentaplegicis virtually the same as the plane in double-dorsal duplications caused by wingless. It divides the fate map into two parts, each bisected by the dorsoventral axis. In the double mutant decapentaplegic winglessthe most ventral and dorsal tarsal structures are missing, consistent with the notion that both gene products function as morphogens. In wingless Distal-lesscompounds the legs are severely truncated, indicating an important interaction between these genes. Distal-lessand decapentaplegicmanifest a relatively mild synergism when combined. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 0949944X 1432041X |
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| DOI: | 10.1007/BF00457802 |