Periodical
Acute cold and chronic heatexposure upregulate hepatic leptin and muscle uncoupling protein UCP gene expression in broiler chickensAbbreviationsATPadenosine triposphateBATbrown adipose tissueFASfatty acid synthaseGAPDHglyceraldehyde3phosphate dehydrogenaseRIAradioimmunoassayROSreactive oxygen speciesSCDstearoylCoA desaturaseUCPuncoupling protein.
| العنوان: | Acute cold and chronic heatexposure upregulate hepatic leptin and muscle uncoupling protein UCP gene expression in broiler chickensAbbreviationsATPadenosine triposphateBATbrown adipose tissueFASfatty acid synthaseGAPDHglyceraldehyde3phosphate dehydrogenaseRIAradioimmunoassayROSreactive oxygen speciesSCDstearoylCoA desaturaseUCPuncoupling protein. |
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| المؤلفون: | Dridi, Sami, Temim, Soraya, Derouet, Michel, Tesseraud, Sophie, Taouis, Mohammed |
| المصدر: | Journal of Experimental Zoology Part A: Ecological Genetics and Physiology; August 2008, Vol. 309 Issue: 7 p381-388, 8p |
| مستخلص: | Emerging evidence showed that variations in environmental temperature affect both leptin and uncoupling protein UCP gene expression in mammals, whereas a little is known about such interactions in birds. Thus, we conducted the present study to investigate the influence of acute 2 hours cold 4°C and chronic 10 days heat 32°C exposure on hepatic leptin and muscle UCP gene expression in 5wkold broiler chickens. Both cold and heatexposure significantly P<0.05 to P<0.001 upregulated hepatic leptin by 35 and 46, respectively and muscle UCP mRNA levels by 71 and 71, respectively compared to the thermoneutrality 22°C. This result suggests that leptin and UCP may be involved in the thermoregulation response of chickens to extreme climate cold and hot temperatures. The upregulation of hepatic leptin gene expression was accompanied by an increase in plasma leptin levels, indicating that leptin may be regulated at transcriptional level. The increase of leptin and UCP mRNA abundance, and leptinemia we report here were not related to plasma glucose or insulin levels.In conclusion, the exposure of broiler chickens to extreme ambient temperatures cold and heat increases hepatic leptin and muscle UCP gene expression. J. Exp. Zool. 309A:381–388, 2008. © 2008 WileyLiss, Inc. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 19325223 19325231 |
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| DOI: | 10.1002/jez.461 |