Periodical
Prevalence of β0 and β+ Thalassemia Genes in Greek Children with Homozygous β-Thalassemia
| العنوان: | Prevalence of β0 and β+ Thalassemia Genes in Greek Children with Homozygous β-Thalassemia |
|---|---|
| المؤلفون: | Kattamis, Christos, Karambula, Katerina, Metaxotou-Mavromati, Anna, Ladis, Vasilios, Constantopoulos, Andreas |
| المصدر: | Hemoglobin; 1978, Vol. 2 Issue: 1 p29-46, 18p |
| مستخلص: | In an attempt to estimate the prevalence of β0 and β+thalassemia genes in Greece chromatographic analysis of hemoglobins was performed in 30 children with homozygous β-thalassemia prior to any transfusion. In 13 (43%) no HbA was detected, suggesting the presence of β0 gene in the homozygous state (β0/β thal). In the remaining 17, HbA showed a bimodal distribution with values ranging from 4-36%. The detection of HbA suggests the presence of β+ gene, while the bimodal distribution could be explained by the assumption that the β+ gene in single dose and in combination with β0 gene (β0/β+ thai) results in the production of small amounts of HbA ranging from 4-11%, (first curve), while in double dose (β+/β+ thal), in the production of higher amounts of HbA ranging from 24-36% (second curve). The β0/β+ thai was observed in 11 (37%), and the β+/β+ thai in 6(20%). It is concluded that both β0 and β+genes are common in Greece and chromatographic analysis helps to determine the genotype of patients with homozygous β-thalassemia. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 03630269 1532432X |
|---|---|
| DOI: | 10.3109/03630267808999186 |