Structure−Activity Relationships of Novel Hematoregulatory Peptides

التفاصيل البيبلوغرافية
العنوان: Structure−Activity Relationships of Novel Hematoregulatory Peptides
المؤلفون: Bhatnagar, P. K., Agner, E. K., Alberts, D., Arbo, B. E., Callahan, J. F., Cuthbertson, A. S., Engelsen, S. J., Fjerdingstad, H., Hartmann, M., Heerding, D., Hiebl, J., Huffman, W. F., Hysben, M., King, A. G., Kremminger, P., Kwon, C., LoCastro, S., Lovhaug, D., Pelus, L. M., Petteway, S., Takata, J. S.
المصدر: Journal of Medicinal Chemistry; September 13, 1996, Vol. 39 Issue: 19 p3814-3819, 6p
مستخلص: Hematopoiesis is a lifelong cell renewal process regulated by a family of lineage specific hematopoietic growth factors. Several hematopoietic growth factors such as G-CSF, GM-CSF, and M-CSF have been clinically evaluated for enhancement of host defense in normal and immunocompromised patients and for the treatment of infectious diseases. This paper reports the structure−activity relationships of low molecular weight hematoregulatory peptides based on a nonapeptide (1, SK&F 107647). Like the macromolecular growth factors, these peptides modulate host defense. A molecular target for this class of compounds has not yet been identified. However, the structure−activity relationships established by this study implicate a very specific molecular recognition event that is pivotal for the biological activities of 1 and its analogues.
قاعدة البيانات: Supplemental Index