التفاصيل البيبلوغرافية
| العنوان: |
Gut microbial GABAergic signaling improves stress-associated innate immunity to respiratory viral infection. |
| المؤلفون: |
Gao, Yanan, Liang, Zihao, Mao, Bingyong, Zheng, Xudong, Shan, Jinjun, Jin, Cuiyuan, Liu, Shijia, Kolliputi, Narasaiah, Chen, Yugen, Xu, Feng, Shi, Liyun |
| المصدر: |
Journal of Advanced Research; Jun2024, Vol. 60, p41-56, 16p |
| مستخلص: |
[Display omitted] • Psychological stress exacerbates respiratory viral infection via disturbing gut microbiome. • Psychological stress specifically reduces Lactobaceace abundance and GABA level. • Microbial GABA regulates AMs homeostasis via the αKG/TET2/PPARγ axis. • Replenishment of GABA-metabolizing bacteria reverses adverse effect of stress on viral pneumonia. Epidemiological evidences reveal that populations with psychological stress have an increased likelihood of respiratory viral infection involving influenza A virus (IAV) and SARS-CoV-2. This study aims to explore the potential correlation between psychological stress and increased susceptibility to respiratory viral infections and how this may contribute to a more severe disease progression. A chronic restraint stress (CRS) mouse model was used to infect IAV and estimate lung inflammation. Alveolar macrophages (AMs) were observed in the numbers, function and metabolic-epigenetic properties. To confirm the central importance of the gut microbiome in stress-exacerbated viral pneumonia, mice were conducted through microbiome depletion and gut microbiome transplantation. Stress exposure induced a decline in Lactobacillaceae abundance and hence γ-aminobutyric acid (GABA) level in mice. Microbial-derived GABA was released in the peripheral and sensed by AMs via GABA A R, leading to enhanced mitochondrial metabolism and α-ketoglutarate (αKG) generation. The metabolic intermediator in turn served as the cofactor for the epigenetic regulator Tet2 to catalyze DNA hydroxymethylation and promoted the PPARγ-centered gene program underpinning survival, self-renewing, and immunoregulation of AMs. Thus, we uncover an unappreciated GABA/Tet2/PPARγ regulatory circuitry initiated by the gut microbiome to instruct distant immune cells through a metabolic-epigenetic program. Accordingly, reconstitution with GABA-producing probiotics, adoptive transferring of GABA-conditioned AMs, or resumption of pulmonary αKG level remarkably improved AMs homeostasis and alleviated severe pneumonia in stressed mice. Together, our study identifies microbiome-derived tonic signaling tuned by psychological stress to imprint resident immune cells and defensive response in the lungs. Further studies are warranted to translate these findings, basically from murine models, into the individuals with psychiatric stress during respiratory viral infection. [ABSTRACT FROM AUTHOR] |
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