التفاصيل البيبلوغرافية
| العنوان: |
Oral 5-aminolevulinic acid combined with sodium ferrous citrate prevents blood–aqueous barrier breakdown after anterior chamber paracentesis in healthy beagle dogs. |
| المؤلفون: |
Yuya OTAKA, Kazutaka KANAI, Aoi TOMATSU, Riyo SANGU, Daiki OKADA, Noriaki NAGAI, Yohei YAMASHITA, Yoichiro ICHIKAWA, Aki SAKAI, Kazuki TAJIMA |
| المصدر: |
Journal of Veterinary Medical Science; 2023, Vol. 85 Issue 12, p1257-1260, 4p |
| مصطلحات موضوعية: |
BEAGLE (Dog breed), PARACENTESIS, CITRATES, SODIUM, AQUEOUS humor, ACIDS |
| مستخلص: |
This study investigated the preventive effect of 5-aminolevulinic acid combined with sodium ferrous citrate (5-ALA/SFC) on blood–aqueous barrier (BAB) breakdown induced after anterior chamber paracentesis (ACP) in beagles. 5-ALA/SFC (1/0.64 mg/kg or 3/1.92 mg/kg) or carprofen (4.0 mg/kg) was orally administered daily for 7 days prior to ACP. Then, a sample of the aqueous humor (AH) was collected from one eye via ACP (first sample) and again 60 min later (second sample). The protein and prostaglandin E2 (PGE2) concentrations in both samples were measured. Compared with the control group, high-dose 5-ALA/SFC and carprofen significantly reduced the AH protein and PGE2 concentrations in the second sample. Our findings suggest that 5-ALA/SFC suppresses BAB breakdown in dogs. [ABSTRACT FROM AUTHOR] |
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