التفاصيل البيبلوغرافية
| العنوان: |
Ecogenetics of Pancreatic Cancer: A Registry of Cancer Families. |
| المؤلفون: |
Mulvihill, John J., Shapiro, Andrew, Emmick, Jason G., Crowley, Kerry E., Rodriguez, Carina J., Banke, Michael G., McNamara, Patrick L., Aston, Christopher E., Finkelstein, Sidney D., Virji, Mohamed A. |
| المصدر: |
Familial Cancer & Prevention: Molecular Epidemiology: A New Strategy Toward Cancer Control; 1999 1st Edition, p363-368, 6p |
| مستخلص: |
Width support from the American Cancer Society and the U.S. National Cancer Institute, we launched a registry of that now consists of 90 families who met one of two inclusion criteria: at least two first-degree relatives with cancer of the exocrine pancreas, or two affected second-degree relatives connected by a relative with any other type of cancer. Family members completed questionnaires on demographics, cancer history, family history, psychological scales, benefits and barriers to participation, motivators for participation, and the participants' expectations and experiences. In preliminary analyses, families demonstrated an increased number of cancers, as compared with the general population. Relatives showed significant increases in the numbers of breast. colon, gastric and male genital cancers. The two groups, those aggregating disease at the most stringent P-value (<0.001) and those not aggregating at the least stringent P-value level (<0.05), represented the retest likely candidates for familial cases and sporadic cases, respectively. Segregation analysis was conducted with 10 possible models, two environmental and eight genetic: the most likely model for pancreatic cancer susceptibility in the t-antilles was that of a dialectic major gene with a dominant disease allele controlling the age of onset. Research on these 90 families and on additional families continues in the hope of finding genetic determinants, environmental modifiers, and early detection strategies. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Supplemental Index |