التفاصيل البيبلوغرافية
| العنوان: |
Refinement of Ischemic Stroke Risk in Patients with Atrial Fibrillation and CHA2DS2-VASc Score of 1. |
| المؤلفون: |
HUANG, DUO, ANGUO, LUO, YUE, WEN‐SHENG, YIN, LIXUE, TSE, HUNG‐FAT, SIU, CHUNG‐WAH |
| المصدر: |
Pacing & Clinical Electrophysiology; Nov2014, Vol. 37 Issue 11, p1442-1447, 6p |
| مصطلحات موضوعية: |
STROKE risk factors, FIBRINOLYTIC agents, ANALYSIS of variance, ATRIAL fibrillation, CEREBRAL ischemia, CONFIDENCE intervals, FISHER exact test, LONGITUDINAL method, STATISTICAL hypothesis testing, T-test (Statistics), PROPORTIONAL hazards models, RETROSPECTIVE studies, DATA analysis software, DESCRIPTIVE statistics, KAPLAN-Meier estimator, LOG-rank test |
| مستخلص: |
Background Patients with atrial fibrillation (AF) with CHA2DS2-VASc score of 1 (where CHA2DS2-VASc is CHA 2DS 2-Vascular disease, Age 65-74 years, Sex category) are recommended to receive antithrombotic therapy. Nonetheless, it remains unclear whether individual components that constitute CHA2DS2-VASc score contribute equally to the ischemic stroke risk, particularly in patients with CHA2DS2-VASc score of 1. The objective was to describe and compare the risk of ischemic stroke of the six individual components constituting CHA2DS2-VASc among AF patients with CHA2DS2-VASc score of 1. Methods and Results We studied all patients with CHA2DS2-VASc score of 1 and no antithrombotic therapy from our cohort of 9,727 Chinese AF patients. A total of 548 patients were studied: 190 patients with CHA2DS2-VASc score of 0 and 358 patients with CHA2DS2-VASc score of 1. Of those with a baseline CHA2DS2-VASc score of 1, 51.1% patients aged 65-75; 29.3% patients were female; 12.0% had hypertension; 4.5% had heart failure; 2.5% had diabetes; and 0.6% had vascular disease. After 1,758 patient-years of follow-up, the annual incidence of stroke was 2.4% and 6.6% for patients with CHA2DS2-VASc score of 0 and 1, respectively. Compared with patients with CHA2DS2-VASc score of 0, patients with hypertension leading to CHA2DS2-VASc score of 1 were at the highest risk of stroke (Hazard ratio [HR]: 9.8, 95% confidence interval [CI]: 2.7-35.6), followed by patients aged 65-74 (HR: 3.9, 95% CI: 2.3-6.6) and female gender (HR: 2.3, 95% CI: 1.1-4.8). Heart failure, diabetes mellitus, and vascular disease were not associated with stroke. Conclusion In AF patients with CHA2DS2-VASc score of 1, hypertension confers the highest risk for stroke among other risk factors comprising the score. A more aggressive thromboprophylaxis strategy may be justified among AF patients with CHA2DS2-VASc score of 1 due to hypertension. [ABSTRACT FROM AUTHOR] |
|
Copyright of Pacing & Clinical Electrophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |