التفاصيل البيبلوغرافية
| العنوان: |
Urinary concentration does not exclusively rely on plasma vasopressin. A study between genders Gender and diurnal urine regulation. |
| المؤلفون: |
Graugaard‐Jensen, C., Hvistendahl, G. M., Frøkiær, J., Bie, P., Djurhuus, J. C. |
| المصدر: |
Acta Physiologica; Sep2014, Vol. 212 Issue 1, p97-105, 9p |
| مصطلحات موضوعية: |
VASOPRESSIN, URINATION, CIRCADIAN rhythms, BLOOD plasma, OSMOLALITY, SEX differences (Biology) |
| مستخلص: |
Aim We investigated the influence of gender on the diurnal regulation of urine production with special focus on vasopressin, oxytocin and prostaglandin E2. Methods Fifteen young women in mid-follicular phase and 22 young men (20-33 years) were included. All participants underwent a 24-h circadian inpatient study under standardized conditions for measurements of plasma vasopressin, oxytocin, sodium and osmolality. Urine was fractionally collected for measurements of electrolytes, aquaporin-2 and prostaglandin E2. Results Plasma vasopressin expressed a diurnal rhythm with a night-time increase in both genders ( P < 0.001). The ratio between mean daytime and mean night-time was 1.57 [95% CI: 1.33-1.84] P < 0.001 in men and 1.35 [95% CI: 1.11-1.64] P = 0.002 in women. P-vasopressin was higher in males during the night ( P < 0.05). There was no difference in diuresis ( P = 0.43), urine osmolality ( P = 0.12) or aquaporin-2 excretion ( P = 0.80) between genders. We found a trend towards a higher reabsorption of free water in males ( P = 0.07). The excretion of prostaglandin E2 was higher in males ( P < 0.001). There was no diurnal rhythm in p-oxytocin ( P = 0.37) and no correlation to diuresis, urine osmolality or aquaporin-2 excretions. Conclusion Similar urinary flows and osmolalities are associated with levels of plasma vasopressin and renal PGE2, which are higher in males than in females. Oxytocin does not seem to play a role in the diurnal urine formation, whereas prostaglandin E2 could represent a mediator of the gender difference, not only as a mediator of the vasopressin response, but also as an independent factor. These findings need further elucidation. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |