التفاصيل البيبلوغرافية
| العنوان: |
PTEN regulates hair cell proliferation, differentiation and innervation in the mammalian inner ear. |
| المؤلفون: |
Dong, Y., Sui, L., Yamaguchi, F., Kamitori, K., Hirata, Y., Hossain, A., Suzuki, A., Tokuda, M. |
| المصدر: |
Proceedings of the Physiological Society; 2013, p664P-664P, 1/3p |
| مصطلحات موضوعية: |
PTEN protein, TUMOR suppressor proteins, SYNAPTOGENESIS |
| مستخلص: |
PTEN (phosphatase and tensin homolog deleted on chromosome 10) is a tumor suppressor gene that regulates various cell processes including proliferation, growth, synaptogenesis and the dynamics of the actin-myosin cytoskeleton. We studied the expression pattern of PTEN in the mouse inner ear during development and explored its function by analysis of PTEN heterozygous null mice. Immunolabeling revealed that PTEN is expressed primarily in differentiating sensory neurons and hair cells, coinciding with the temporal and spatial gradients of hair cell differentiation. In heterozygous null mice the sensory epithelial progenitors withdraw later from the cell cycle than wild type and this is associated with an increase in hair cell number. Disorganization and loss of hair bundles is uniquely associated with the formation of ectopic hair bundles on the inner pillar cells. These results show that PTEN plays an important role in regulating the proliferation, differentiation and innervation of mammalian cochlear hair cells. PTEN signaling pathways provide potential therapeutic targets for the regeneration of mammalian inner ear sensory epithelia. [ABSTRACT FROM AUTHOR] |
|
Copyright of Proceedings of the Physiological Society is the property of Physiological Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |