التفاصيل البيبلوغرافية
| العنوان: |
Diffraction-limited ultrasensitive molecular nano-arrays with singular nano-cone scattering. |
| المؤلفون: |
Yunshan Wang, Ting-Chou Chang, Stoddart, Paul R., Hsueh-Chia Chang |
| المصدر: |
Biomicrofluidics; Apr2014, Vol. 8 Issue 2, p1-4, 4p |
| مصطلحات موضوعية: |
DIFFRACTIVE scattering, MICROARRAY technology, METAL fabrication, WAVE amplification, FLUORESCENCE, MOLECULAR dynamics |
| مستخلص: |
Large-library fluorescent molecular arrays remain limited in sensitivity (1×106 molecules) and dynamic range due to background auto-fluorescence and scattering noise within a large (20-100 μm) fluorescent spot. We report an easily fabricated silica nano-cone array platform, with a detection limit of 100 molecules and a dynamic range that spans 6 decades, due to point (10 nm to 1 μm) illumination of preferentially absorbed tagged targets by singular scattering off wedged cones. Its fluorescent spot reaches diffraction-limited submicron dimensions, which are 104 times smaller in area than conventional microarrays, with comparable reduction in detection limit and amplification of dynamic range. [ABSTRACT FROM AUTHOR] |
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