التفاصيل البيبلوغرافية
| العنوان: |
Influence of HbA1c on short-term blood pressure variability in type 2 diabetic patients with diabetic nephropathy. |
| المؤلفون: |
Liu, Fang, Wu, Min, Feng, Yan-huan, Zhong, Hui, Cui, Tian-lei, Huang, You-qun, Liang, Ya-ping, Diao, Yong-shu, Zang, Li, Li, Ling, Zang, Jing, Qiu, Hong-yu, Huang, Song-min, Fu, Ping |
| المصدر: |
Journal of Zhejiang University: Science B; Nov2013, Vol. 14 Issue 11, p1033-1040, 8p |
| مستخلص: |
The aim of this study was to understand the characteristics of blood pressure (BP) variability in subjects with diabetic nephropathy (DN), and identify the probable predictors affecting BP variability. Fifty-one chronic kidney disease (CKD)-hypertensive patients without diabetes (NDN group) and sixty type 2 diabetic patients with overt DN (DN group) were enrolled in this study. The values of short-term BP variability were obtained from 24 h ambulatory BP monitoring (ABPM). Variance analysis or nonparametric analysis revealed that 24-h systolic BP variability and nighttime systolic BP variability of the DN group were significantly higher than those of the NDN group [(12.23±3.66) vs. (10.74±3.83) mmHg, P<0.05; (11.23±4.82) vs. (9.48±3.69) mmHg, P<0.05]. Then the patients of the DN group were divided into two groups according to glycated hemoglobin (HbA1c) level: Group A (HbA1c<7%) and Group B (HbA1c≥7%), and the t-test showed that patients in Group B had larger 24-h diastolic, daytime diastolic, and nighttime systolic/diastolic BP variability compared with Group A. In the DN group, partial correlation analysis revealed that HbA1c exhibited a strong association with 24-h diastolic, daytime diastolic, nighttime systolic and diastolic BP variability ( P<0.001, P<0.001, P<0.05, and P<0.001, respectively). Taken together, larger short-term BP variability was detected in hypertensive type 2 diabetic patients with overt nephropathy and renal insufficiency. It may imply that the optimal BP variability level could benefit from a better glycaemic control. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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