التفاصيل البيبلوغرافية
| العنوان: |
Treatment of childhood acute myelogenous leukemia with an intensive regimen (AML-87) that individualizes etoposide and cytarabine dosages: short- and long-term effects. |
| المؤلفون: |
Arnaout, M K, Radomski, K M, Srivastava, D K, Tong, X, Belt, J R, Raimondi, S C, Behm, F G, Santana, V M, Crom, W R, Mirro, J, Ribeiro, R C, Mirro, J Jr |
| المصدر: |
Leukemia (08876924); Oct2000, Vol. 14 Issue 10, p1736-1742, 7p |
| مصطلحات موضوعية: |
ACUTE myeloid leukemia, ETOPOSIDE |
| مستخلص: |
The purpose of this study was to assess the feasibility and efficacy of a treatment regimen for pediatric acute myelogenous leukemia (AML) that uses four rotating drug pairs and adjusts dosages of etoposide and cytarabine to target specific plasma concentrations. Thirty-one girls and 27 boys (median age, 9.7 years) with de novo AML were treated on the protocol. Six cycles of chemotherapy were planned. Cycles 1 to 4 comprised the drug combinations cytarabine plus etoposide, cytarabine plus daunomycin, etoposide plus amsacrine, and etoposide plus azacitidine, respectively. For cycles 5 and 6, the first two combinations were repeated. Dosages were adjusted to achieve plasma concentrations of 1.0 microM +/- 0.1 microM cytarabine and 30 microM +/- 0.3 microM etoposide. Forty-four patients (76%) entered complete remission. Of those, 24 have had relapses; 23 remain alive in first or subsequent remission. The 5-year event-free survival (EFS) estimate was 31.0% +/- 5.9%; the 5-year survival estimate was 41.4% +/- 6.3%. Six patients (10%) died of the toxic effects of therapy. Severe neutropenia occurred in all cycles. Long-term complications of therapy included hepatitis C, cardiac insufficiency, and hearing loss. Adjustment of cytarabine and etoposide dosage was feasible for achieving targeted plasma drug concentrations; however, the potential clinical efficacy of this approach was offset by substantial acute and long-term toxicity. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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