التفاصيل البيبلوغرافية
| العنوان: |
HbA1c as a diagnostic tool for diabetes and pre-diabetes: the Bangladesh experience. |
| المؤلفون: |
Bhowmik, B., Diep, L. M., Munir, S. B., Rahman, M., Wright, E., Mahmood, S., Afsana, F., Ahmed, T., Khan, A. K. A., Hussain, A. |
| المصدر: |
Diabetic Medicine; Mar2013, Vol. 30 Issue 3, pe70-e77, 8p, 5 Charts, 1 Graph |
| مصطلحات موضوعية: |
DIAGNOSIS of diabetes, ANALYSIS of covariance, CONFIDENCE intervals, DIABETES, GLYCOSYLATED hemoglobin, EVALUATION of medical care, PREDIABETIC state, RURAL conditions, STATISTICS, SURVEYS, LOGISTIC regression analysis, DATA analysis, ACQUISITION of data, CROSS-sectional method, DIAGNOSIS |
| مصطلحات جغرافية: |
BANGLADESH |
| الشركة/الكيان: |
WORLD Health Organization |
| مستخلص: |
Aims To evaluate HbA1c as a tool for the diagnosis of diabetes and pre-diabetes (impaired glucose tolerance and/or impaired fasting glucose) and to identify the optimal cut-off values suitable for a Bangladeshi population. Methods In this cross-sectional survey in a rural community, 2293 randomly selected individuals aged ≥ 20 years without prior history of diabetes were included. HbA1c and other clinical covariates necessary for the diagnosis of diabetes were recorded. Diabetes and pre-diabetes were defined according to the World Health Organization 1999 criteria. The receiver operating characteristic curve was used to determine the performance of HbA1c. Results The prevalences of diabetes and pre-diabetes were 7.9 and 8.6%, respectively. Based on receiver operating characteristic curve analysis, an HbA1c cut-off value of ≥ 42 mmol/mol (≥ 6.0%) gave an optimal sensitivity of 86.2% and specificity of 93.3%, with an area under the curve of 0.949 to predict diabetes using the oral glucose tolerance test as the gold standard; a cut-off value of ≥ 38 mmol/mol (≥ 5.6%) gave an optimal sensitivity of 68.0% and specificity of 66.4%, with an area under the curve of 0.714 to predict pre-diabetes. In subjects at high risk of diabetes, HbA1c ≥ 42 mmol/mol (≥ 6.0%) showed higher sensitivity than fasting plasma glucose ≥ 7.0 mmol/l, 2-h plasma glucose ≥ 11.1 mmol/l and HbA1c ≥ 48 mmol/mol (≥ 6.5%). Conclusions An HbA1c cut-off value of ≥ 42 mmol/mol (≥ 6.0%) was highly sensitive and specific in diagnosing diabetes mellitus. This optimal cut-off level may be suitable as a diagnostic criterion for diabetes in a Bangladeshi population. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |