التفاصيل البيبلوغرافية
| العنوان: |
Isolation and biological activity of triglycerides of the fermented mushroom of Coprinus comatus. |
| المؤلفون: |
Jun Ren, Jin-Li Shi, Chun-Chao Han, Zhen-Quan Liu, Jian-You Guo |
| المصدر: |
BMC Complementary & Alternative Medicine; 2012, Vol. 12 Issue 1, p52-56, 5p, 3 Charts, 2 Graphs |
| مصطلحات موضوعية: |
ANALYSIS of triglycerides, ANALYSIS of variance, ANIMAL experimentation, ANTI-inflammatory agents, ANTIOXIDANTS, BIOPHYSICS, CYTOKINES, ENZYME-linked immunosorbent assay, HYPERALGESIA, RESEARCH methodology, MICE, MUSHROOMS, NOCICEPTORS, RESEARCH funding, STATISTICS, TOXICITY testing, PLANT extracts, DATA analysis, DESCRIPTIVE statistics |
| مستخلص: |
Background: Although many physiological functions of Coprinus comatus have been reported, there has been no report on the antinociceptive activity of Coprinus comatus. Therefore, the objective of the present study is to demonstrate the production, isolation, and biological properties of triglycerides (TFC) of the fermented mushroom of Coprinus comatus. Methods: The effects of TFC on cytokines levels, total antioxidant activity, antinociceptive effects in vivo, LD50 and tactile hyperalgesia were analyzed respectively. Results: TFC treatment decreased the levels of cytokines and total antioxidant status (TAOS) and inhibited the acetic acid-induced abdominal constrictions in mice. In addition, TFC reduced CFA-induced tactile hyperalgesia in a dose-dependent manner and the LD50 of TFC was determined to be 400 mg/kg. However, TFC did not significantly inhibit the reaction time to thermal stimuli in the hot-plate test. Conclusions: TFC showed anti-inflammatory, antioxidant, peripheral antinociceptive and antihyperalgesic activity in various models of inflammatory pain. The data suggest that TFC may be a viable treatment option for inflammatory pain. [ABSTRACT FROM AUTHOR] |
|
Copyright of BMC Complementary & Alternative Medicine is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder