التفاصيل البيبلوغرافية
| العنوان: |
The deamination of dopamine by human brain monoamine oxidase. |
| المؤلفون: |
O'Carroll, Anne-Marie, Fowler, Christopher, Phillips, Jack, Tobbia, Iqdam, Tipton, Keith |
| المصدر: |
Naunyn-Schmiedeberg's Archives of Pharmacology; 1983, Vol. 322 Issue 3, p198-202, 5p |
| مستخلص: |
The deamination of dopamine has been studied in seven regions of human brain. Both A and B forms of the enzyme were found to be active towards this substrate. The ratio of activities of MAO-A: MAO-B was found to vary considerably from brain region to brain region, from about 1∶1 for the cerebral and cerebellar cortex to about 1∶2 for the pons and medula oblongata. Enzyme titration studies and comparisons of the substrate specificities of MAO-A and MAO-B across the brain indicated that dopamine was metabolised by the same MAO active centres as other monoamines. In the cerebral cortex, the K values of MAO-A and-B towards dopamine were found to be 210 and 230 μM, respectively, indicating that the relative contributions of these two forms towards the oxidation of this substrate will not be significantly affected by changes in its concentration. [ABSTRACT FROM AUTHOR] |
|
Copyright of Naunyn-Schmiedeberg's Archives of Pharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |