التفاصيل البيبلوغرافية
| العنوان: |
Dosage adjustment for ceftazidime in patients with impaired renal function. |
| المؤلفون: |
Dalen, R., Vree, T., Baars, A., Termond, E. |
| المصدر: |
European Journal of Clinical Pharmacology; 1986, Vol. 30 Issue 5, p597-605, 9p |
| مستخلص: |
Ceftazidime has good antibacterial activity against many Gram-negative micro-organisms including Ps. aeruginosa. The aim of the present study was to calculate a dosage adjustment regimen for renal failure patients and to test it in a second group of patients. A study was made of the pharmacokinetics of ceftazidime 1 g given as a single bolus i.v. injection in 20 patients in an intensive care unit with varying degrees of renal function, including patients on regular haemodialysis. The serum half-life of elimination (t) varied from 1.6 to 45 h depending on renal function. During haemodialysis the mean t was 4.7 h. A good correlation between the renal clearance of creatinine and ceftazidime was observed. In most patients protein binding was lower than previously observed. From the pharmacokinetic data, a dosage adjustment regimen for patients with renal insufficiency was calculated, which studies in 7 further patients showed to be effective. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |