التفاصيل البيبلوغرافية
| العنوان: |
Serum antibodies to Pseudomonas aeruginosa in cystic fibrosis. |
| المؤلفون: |
BRETT, M. M., GHONEIM, A. T. M., LITTLEWOOD, J. M., Ghoneim, A T |
| المصدر: |
Archives of Disease in Childhood; Nov1986, Vol. 61 Issue 11, p1114-1120, 7p |
| مصطلحات موضوعية: |
LUNG disease diagnosis, IMMUNOGLOBULIN analysis, COMPARATIVE studies, CYSTIC fibrosis, ENZYME-linked immunosorbent assay, LUNG diseases, RESEARCH methodology, MEDICAL cooperation, PSEUDOMONAS, PSEUDOMONAS diseases, RESEARCH, EVALUATION research, BACTERIAL antibodies, DISEASE complications |
| مستخلص: |
Serum IgG antibodies to Pseudomonas aeruginosa cell surface antigens were determined by enzyme linked immunosorbent assay. Titres in patients without cystic fibrosis were low (140-235). Those in patients with cystic fibrosis who were chronically infected by P. aeruginosa were very high (1100-20,500), while patients who grew the organism intermittently had lower titres (160-4400). Longitudinal studies showed that raised titres were observed at a very early stage of infection. High titres were associated with a poor clinical state, while low titres were associated with a better clinical state in both chronic and intermittently infected patients with cystic fibrosis. These results suggest that this test is a specific and sensitive measure of the severity and progress of the different stages of pulmonary infection by P. aeruginosa in patients with cystic fibrosis. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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