التفاصيل البيبلوغرافية
| العنوان: |
Insulin deficiency exacerbates cerebral amyloidosis and behavioral deficits in an Alzheimer transgenic mouse model. |
| المؤلفون: |
Xu Wang, Wei Zheng, Jing-Wei Xie, Tao Wang, Si-Ling Wang, Wei-Ping Teng, Zhan-You Wang |
| المصدر: |
Molecular Neurodegeneration; 2010, Vol. 5, p46-58, 13p |
| مصطلحات موضوعية: |
ALZHEIMER'S disease, NEUROLOGICAL disorders, PROTEIN metabolism disorders, LYMPHOPROLIFERATIVE disorders, HORMONE receptors |
| مستخلص: |
Background: Although increasing evidence has indicated that brain insulin dysfunction is a risk factor for Alzheimer disease (AD), the underlying mechanisms by which insulin deficiency may impact the development of AD are still obscure. Using a streptozotocin (STZ)-induced insulin deficient diabetic AD transgenic mouse model, we evaluated the effect of insulin deficiency on AD-like behavior and neuropathology. Results: Our data showed that administration of STZ increased the level of blood glucose and reduced the level of serum insulin, and further decreased the phosphorylation levels of insulin receptors, and increased the activities of glycogen synthase kinase-3α/β and c-Jun N-terminal kinase in the APP/PS1 mouse brain. We further showed that STZ treatment promoted the processing of amyloid-β (Aβ) precursor protein resulting in increased Aβ generation, neuritic plaque formation, and spatial memory deficits in transgenic mice. Conclusions: Our present data indicate that there is a close link between insulin deficient diabetes and cerebral amyloidosis in the pathogenesis of AD. [ABSTRACT FROM AUTHOR] |
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