Academic Journal
Testicular disease in acute lymphoblastic leukemia in childhood.
| العنوان: | Testicular disease in acute lymphoblastic leukemia in childhood. |
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| المؤلفون: | Eden, O.B., Hardisty, R.M., Innes, E.M., Kay, H.E.M., Peto, J. |
| المصدر: | British Medical Journal; 2/11/1978, Vol. 1 Issue 6109, p334-338, 5p, 3 Charts, 6 Graphs |
| مصطلحات موضوعية: | LYMPHOBLASTIC leukemia in children, TESTICULAR diseases, THROMBOCYTOPENIA |
| مستخلص: | In three trials conducted by the Medical Research Council on acute lymphoblastic leukaemia in childhood the incidence of testicular infiltration in relation to presenting features and treatment was analysed. Initial severe thrombocytopenia was associated with an increased incidence. Testicular infiltration was occasionally found during treatment in patients with high blood leucocyte counts at diagnosis but the main incidence in patients with all types of disease occurred within one year of stopping treatment. The incidence may be increased when "second-line" drugs, especially cyclophosphamide, have been used. A reappraisal of the value of additional drugs in maintenance treatment of patients with good prognosis is needed. The incidence of leukaemic infiltration of the testis as a complication of acute lymphoblastic leukaemia (ALL) in childhood has increased as longer remissions from bone-marrow and meningeal disease have been achieved. In this paper we review The incidence and circumstances of testicular disease in there trials conducted by the Medical Research Council. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: | Complementary Index |
Full Text Finder | تدمد: | 00071447 |
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| DOI: | 10.1136/bmj.1.6109.334 |