التفاصيل البيبلوغرافية
| العنوان: |
The role of cigarette smoking and statins in the development of postmenopausal osteoporosis: a pilot study utilizing the Marshfield Clinic Personalized Medicine Cohort. |
| المؤلفون: |
Giampietro, P. F., McCarty, C., Mukesh, B., McKiernan, F., Wilson, D., Shuldiner, A., Liu, J., LeVasseur, J., Ivacic, L., Kitchner, T., Ghebranious, N. |
| المصدر: |
Osteoporosis International; Mar2010, Vol. 21 Issue 3, p467-477, 11p, 7 Charts |
| مصطلحات موضوعية: |
CIGARETTE smokers, STATINS (Cardiovascular agents), POSTMENOPAUSE, OSTEOPOROSIS in women, GENETIC polymorphisms |
| مستخلص: |
A cohort of postmenopausal osteoporotic females and controls with normal bone mineral density, the interleukin 6 ( IL6) −634G > C (rs1800796) C allele of the promoter region showed association with osteoporosis. The lipoprotein receptor-related protein 5 ( LRP5) gene showed association between C135242T C/T alleles and osteoporosis only in smokers, suggesting a role for environmental interaction. A nested case–control study within a population-based cohort was undertaken to assess the relative impact of cigarette smoking, statin use, genetic polymorphisms, and one-way interaction of these factors on development of osteoporosis in postmenopausal women. Genotyping of 14 single-nucleotide polymorphisms (SNPs) corresponding to vitamin D receptor gene, estrogen receptor 1, collagen type 1 alpha 1, IL6, transcription growth factor beta, apolipoprotein E, and LRP5 genes was performed in cases ( n = 309) with osteoporosis and controls ( n = 293) with normal bone mineral density drawn from a homogeneous Caucasian population. SNPs were chosen based on known functional consequences or prior evidence for association and genotyped using matrix-assisted laser desorption ionization time-of-flight technology. Cases differed from controls relative to body mass index, age, and smoking but not statin use. After adjusting for age, the IL6 −634G > C (rs1800796) allele showed association with osteoporosis (odds ratio (OR) for CC + CG = 2.51, p = 0.0047)), independent of statin use or smoking status. On stratification for smoking, association with LRP5 C135242T (rs545382) and osteoporosis emerged (OR 2.8 in smokers for CT alleles, p = 0.03)), suggestive of potential environmental interaction. Evidence suggested a role for genetic variation in IL6 and LRP5 in conferring risk for osteoporosis in Caucasian women, with the latter manifest only in smokers. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |