التفاصيل البيبلوغرافية
| العنوان: |
Dietary Conjugated Linoleic Acids Decrease Leptin in Porcine Adipose Tissue. |
| المؤلفون: |
Alessia Di Giancamillo, Rossi, Raffaella, Vitari, Francesca, Pastorelli, Grazia, Corino, Carlo, Domeneghini, Cinzia |
| المصدر: |
Journal of Nutrition; Oct2009, Vol. 139 Issue 10, p1867-1872, 6p |
| مصطلحات موضوعية: |
LINOLEIC acid, LEPTIN, ADIPOSE tissues, LABORATORY swine, IMMUNOHISTOCHEMISTRY techniques, WESTERN immunoblotting, SWINE nutrition, PROTEINS in animal nutrition, DIETARY supplements, LIPIDS |
| مستخلص: |
We investigated the effects of dietary conjugated linoleic acids (CLA) on white adipose tissue (WAT) in heavy pigs. Twelve pigs were assigned to 1 of 2 groups supplemented with either 0 or 0.75% of a CLA preparation lisomeric mixture) and were slaughtered at 159 ± 2.3 kg live weight. Their subcutaneous WAT was analyzed by both chemical and microanatomical methods. The WAT of CLA-fed pigs tended to have a higher protein content (P = 0.064) and smaller adipocytes (P= 0.053) than that of control (CTR) pigs. The number of proliferating preadipocytes tended to be greater (P= 0.076) in pigs fed CLA, whereas the number of apoptotic adipocytes was greater (P < 0.01) than in CTR pig. Immunohistochemistry revealed that leptin (Ob) expression was lower (P = 0.048) in adipocytes from treated pigs and Western blot quantification of Ob revealed lower levels (P < 0.05) in CLA-fed pigs. The Ob receptor was not affected by dietary CLA supplementation. Tyrosine hydroxylase activity was higher (P < 0.001) in WAT of CLA fed-pigs than in CTR. It is conceivable that the increased noradrenergic activity due to dietary CLA decreases the Ob expression, although it does not diminish the lipid content of WAT, at least in heavy pigs. This article describes the interaction between CLA and Ob in the WAT of heavy pigs and we hypothesize that there is an increased noradrenergic stimulation of lipolysis directly in the target tissue. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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