التفاصيل البيبلوغرافية
| العنوان: |
Matrine inhibits PMA-induced MMP-1 expression in human dermal fibroblasts. |
| المؤلفون: |
Eunsun Jung, Jongsung Lee, Sungran Huh, Jienny Lee, Hyunjin Hwang, Youngsoo Kim, Yong-Woo Kim, Sang Yo Byun, Deokhoon Park |
| المصدر: |
Biofactors; 2008, Vol. 33 Issue 2, p121-128, 8p, 1 Diagram, 1 Chart, 4 Graphs |
| مصطلحات موضوعية: |
METALLOPROTEINASES, EXTRACELLULAR matrix, MACROMOLECULES, FIBROBLASTS, MESSENGER RNA, PROTEIN kinases |
| مستخلص: |
Matrix metalloproteinase-1 (MMP-1) plays an important role in the maintenance and turnover of extracellular matrix (ECM) macromolecules. Remodelling of extracellular matrix by MMPs is a hallmark feature of physiological and pathological processes. In this study, in order to establish the therapeutic potential of matrine, we investigated its effect on MMP-1 expression in human dermal fibroblast cells. We found that matrine inhibited both MMP-1 mRNA and protein expression induced by PMA (phorbol myristate acetate). Therefore, we characterized the inhibitory mechanism of matrine on PMA-induced MMP-1 expression. Matrine inhibited PMA-induced activation of the AP-1 promoter, an important nuclear transcription factor in MMP-1 expression. Additionally, we detected that matrine suppressed the PMA-induced phosphorylation of two mitogenactivated protein kinases, extracellular signal-regulated protein kinase and c-Jun N-terminal kinase, but did not suppress the PMA-induced phosphorylation of p38 kinase. These results suggest that matrine suppresses PMA-induced MMP-1 expression through inhibition of the AP-1 signaling pathway and also may be beneficial for treatment of some inflammatory skin disorders. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |