التفاصيل البيبلوغرافية
| العنوان: |
Eosinophilic bronchitis-like lesion as the cause of death in a Macaca mulatta: a first case report. |
| المؤلفون: |
Christal, J. L., Hubbard, G. B., Dick, Jr., E. J., Brasky, K. M., Jagirdar, J. |
| المصدر: |
Journal of Medical Primatology; Apr2008, Vol. 37 Issue 2, p63-66, 4p, 1 Color Photograph |
| مصطلحات موضوعية: |
EOSINOPHIL disorders, BRONCHITIS, RESPIRATORY allergy, RHESUS monkeys, ASTHMA |
| مستخلص: |
Background Eosinophilic bronchitis is a recently described, relatively benign condition in humans that is characterized by a corticosteroid-responsive chronic cough and sputum eosinophilia without the abnormalities of airway function seen in asthma. The exact cause of this condition is currently unknown, however has been associated with various occupational exposures in humans. It has also been reported to progress to irreversible airway obstruction. This disease has been reported in dogs and horses, but not in non-human primates. Methods Gross examination of an otherwise healthy 13-year-old, colony-born Macaca mulatta, which died of severe non-responsive respiratory distress revealed that the lungs were markedly inflated and moist. Results Hematoxylin and eosin-stained sections from the lungs contained widespread accumulation of eosinophils, sloughed epithelial cells, and mucus centered around bronchioles and adjacent airways. There was no evidence of mast cell infiltration of peribronchiolar smooth muscle, goblet cell hyperplasia, or basement membrane thickening. Conclusions This ruled out recurrent episodes as would be expected in asthma, favoring the diagnosis of an eosinophilic bronchitis-like lesion. We report a first case of eosinophilic bronchitis-like features in a M. mulatta. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of Medical Primatology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |