التفاصيل البيبلوغرافية
| العنوان: |
Impact of amoxicillin, associated or not with clavulanic acid, on pharyngeal colonization and selection of Streptococcus pneumoniae resistance in children under 5 years of age. |
| المؤلفون: |
Conradi, Alvaro Díaz, Calbo, Esther, Cuchí, Eva, Puig, Roger Garcia, García-Rey, César, Boada, Luis Tobeña, Díaz-Infantes, Marisol, Martín-Herrero, José Emilio, Garau, Javier, Conradi, Alvaro Díaz, Cuchí, Eva, García-Rey, César, Boada, Luis Tobeña, Díaz-Infantes, Marisol, Martín-Herrero, José Emilio, Spanish Pneumococcal Infection Study Network |
| المصدر: |
European Journal of Pediatrics; May2007, Vol. 166 Issue 5, p467-471, 5p, 2 Charts |
| مصطلحات موضوعية: |
JUVENILE diseases, STREPTOCOCCUS pneumoniae, DRUG resistance in microorganisms, AMOXICILLIN, CLAVULANIC acid, ANTIBIOTICS, NASOPHARYNX microbiology, CHI-squared test, STREPTOCOCCAL diseases, STREPTOCOCCUS, DISEASE prevalence, PHARMACODYNAMICS, THERAPEUTICS |
| مستخلص: |
Among young children, pneumococcal nasopharyngeal colonization (NPC) rates of >90% have been described. The aim of our study was to assess the effect of amoxicillin exposure on the NPC. From Dec 2001 to Feb 2004, less than 5 years old children with respiratory symptoms and fever who were prescribed amoxicillin were eligible. Three nasopharyngeal swabs were taken: at the time of the initial visit (IV), 60 hours after amoxicillin discontinuation (end of treatment visit, ETV), and 4 weeks later (follow-up visit, FUV). One hundred and thirty four children were included. NPC was detected in 58.5%, 42.9% and 51% of <1, 1-2 and >2 years-old children respectively (NS). Vaccine serotypes (VS) or vaccine-related serotypes (VRS) were identified in 80%, 40% and 55% of <1-year-old, 1-2 year-old and >2-year-old children respectively (NS). The proportion of PNSSP was 60% in <1-year-old children, 43% in 1-2 year-old children and 40% in >2-year-old children (NS). 49 out of 134 (36.5%) children completed the three study visits. 51%, 22.4% and 46.9% of those were colonized at IV, ETV and FUV, respectively (p=0.007). The percentage of resistant SP was 28%, 45.5% and 8.7% (p=0.05) for penicillin. In children <1 year of age, a higher proportion of SP colonization, presence of VS and PNSSP was found. A downfall of NPC at the end of therapy was observed. NPC returned to baseline levels thanks to "de novo" colonization in half of the cases, a few weeks after. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |