التفاصيل البيبلوغرافية
| العنوان: |
Clinical effect of radiation synovectomy of the upper extremity joints: a randomised, double-blind, placebo-controlled study. |
| المؤلفون: |
van der Zant, F. M., Jahangier, Z. N., Moolenburgh, J. D., Swen, W. A. A., Boer, R. O., Jacobs, J. W. G. |
| المصدر: |
European Journal of Nuclear Medicine & Molecular Imaging; Feb2007, Vol. 34 Issue 2, p212-218, 7p, 6 Charts |
| مصطلحات موضوعية: |
SYNOVECTOMY, ARTHRITIS, RADIOISOTOPES, GLUCOCORTICOIDS, JOINTS (Anatomy), INTRA-articular injections |
| مستخلص: |
To compare the clinical efficacy of radiosynoviorthesis (RSO) with intra-articular radionuclide plus glucocorticoid (GC) injection (group A) with that of placebo plus GC injection (group B) for the treatment of persistent synovitis in joints of the upper extremity. At baseline and at 6 and 12 months after intra-articular injection, six clinical parameters were scored. Changes in clinical values over time were summed to provide a change composite index (CCI), ranging from 0 (no effect) to 12 (maximal effect). A CCI ≥6 was considered to indicate successful treatment. Differences in response rate and CCI between groups A and B were examined. Regression analyses were performed to explore whether baseline variables could predict therapeutic effect. Sixty-eight joints in 44 patients were treated. Six months after intra-articular injection, response rates (CCI ≥6) were 69% (25/36) in group A and 29% (9/31) in group B ( p=0.001). The mean CCIs ± standard deviation at 6 months were 6.7±3.2 for group A and 3.3±3.8 for group B ( p=0.001). At 12 months the response rates were 69% (25/36) in group A and 32% (8/25) in group B ( p=0.004). The mean CCIs at 12 months were 6.8±3.3 for group A and 4.2±4.7 for group B ( p= 0.046). None of the baseline variables predicted the therapeutic effect. RSO (radionuclide plus GC) of upper extremity joints with immobilisation for 72 h shows a significantly better response rate than placebo plus GC in patients with persistent synovitis after at least one failed outpatient intra-articular GC injection. [ABSTRACT FROM AUTHOR] |
|
Copyright of European Journal of Nuclear Medicine & Molecular Imaging is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |