التفاصيل البيبلوغرافية
| العنوان: |
CD28‐dependent differentiation into the effector/memory phenotype is essential for induction of arthritis in interleukin‐1 receptor antagonist–deficient mice. |
| المؤلفون: |
Motoko Kotani, Kazuya Hirata, Shuhei Ogawa, Katsuyoshi Habiro, Yasuo Ishida, Seiichi Tanuma, Reiko Horai, Yoichiro Iwakura, Hidehiro Kishimoto, Ryo Abe |
| المصدر: |
Arthritis & Rheumatism; Feb2006, Vol. 54 Issue 2, p473-481, 9p |
| مصطلحات موضوعية: |
INTERLEUKIN-1, RHEUMATOID arthritis, AUTOIMMUNE diseases, ARTHRITIS, T cells |
| مستخلص: |
Interleukin‐1 receptor antagonist (IL‐1Ra)–deficient mice on a BALB/c background spontaneously develop a chronic inflammatory polyarthropathy closely resembling that of rheumatoid arthritis in humans. To elucidate the role of CD28 costimulatory signals in the development of this disease, we studied IL‐1Ra/CD28–double‐deficient mice. We crossed IL‐1Ra–deficient mice with CD28–deficient mice and observed the incidence and severity of arthritis. To investigate functions of IL‐1Ra/CD28–double‐deficient T cells, cells were stimulated with CD3 monoclonal antibody or allogeneic antigen‐presenting cells (APCs) and their proliferative responses and levels of cytokine production were measured.Disease severity was lower in IL‐1Ra/CD28–double‐deficient mice than in mice that were deficient only in IL‐1Ra, although incidence of arthritis was not affected by the presence or absence of CD28. When pathogenic IL‐1Ra–KO T cells were transferred into nude mice, severe arthritis developed. Even though T cells from double‐deficient mice showed the same diminished proliferative capacity as was seen in T cells from CD28–single‐deficient animals, nude mice into which double‐deficient T cells were transferred never developed arthritis.These findings indicate that IL‐1Ra/CD28–double‐deficient T cells can be activated by IL‐1Ra–deficient activated APCs, resulting in induction of arthritis; however, these T cells did not induce the disease under normal conditions, because they did not differentiate into effector/memory phenotype. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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