التفاصيل البيبلوغرافية
| العنوان: |
Complicated urinary tract infections: an update of new and developing antibiotics. |
| المؤلفون: |
Guerriero, Silvia, Matteini, Elena, Gross, Maya M., Gavi, Filippo, Tamburrini, Enrica., Murri, Rita, Torti, Carlo, Sacco, Emilio |
| المصدر: |
Expert Opinion on Pharmacotherapy; Feb2025, Vol. 26 Issue 2, p167-177, 11p |
| مستخلص: |
Introduction: Complicated urinary tract infections (cUTIs) represent a significant clinical challenge due to their association with sepsis, high morbidity and mortality, and an increased risk of recurrence and chronic infection. Effective management requires prompt, targeted interventions. Areas covered: This review highlights the importance of early, targeted antibiotic therapy based on local resistance profiles, patient-specific factors, and pharmacokinetic/pharmacodynamic considerations. We examined emerging and existing antibiotics, including beta-lactams, fluoroquinolones, aminoglycosides, and beta-lactamase inhibitor combinations, which show potential against multidrug-resistant organisms (MDRO) linked to cUTI. Additionally, we propose revisiting the broad definition of cUTI to promote a more pragmatic approach that minimizes unnecessary antibiotic use and hospitalization. Expert opinion: Current evidence underscores the need for antimicrobial stewardship, precise diagnostics, and innovative therapies to address cUTI while mitigating antimicrobial resistance. A targeted, patient-centered approach is essential to optimize outcomes and reduce the burden of resistant infections. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |