التفاصيل البيبلوغرافية
| العنوان: |
Association of Corticosteroid Inhaler Type with Saliva Microbiome in Moderate-to-Severe Pediatric Asthma. |
| المؤلفون: |
Alizadeh Bahmani, Amir Hossein, Abdel-Aziz, Mahmoud I., Hashimoto, Simone, Bang, Corinna, Brandstetter, Susanne, Corcuera-Elosegui, Paula, Franke, Andre, Gorenjak, Mario, Harner, Susanne, Kheiroddin, Parastoo, López-Fernández, Leyre, Neerincx, Anne H., Pino-Yanes, Maria, Potočnik, Uroš, Sardón-Prado, Olaia, Toncheva, Antoaneta A., Wolff, Christine, Kabesch, Michael, Kraneveld, Aletta D., Vijverberg, Susanne J. H. |
| المصدر: |
Biomedicines; Jan2025, Vol. 13 Issue 1, p89, 14p |
| مصطلحات موضوعية: |
METERED-dose inhalers, ORAL microbiology, INHALERS, ASTHMA in children, SALIVA |
| مستخلص: |
Background/Objectives: Metered-dose inhalers (MDIs) and dry powder inhalers (DPIs) are common inhaled corticosteroid (ICS) inhaler devices. The difference in formulation and administration technique of these devices may influence oral cavity microbiota composition. We aimed to compare the saliva microbiome in children with moderate-to-severe asthma using ICS via MDIs versus DPIs. Methods: Saliva samples collected from 143 children (6–17 yrs) with moderate-to-severe asthma across four European countries (The Netherlands, Germany, Spain, and Slovenia) as part of the SysPharmPediA cohort were subjected to 16S rRNA sequencing. The microbiome was compared using global diversity (α and β) between two groups of participants based on inhaler devices (MDI (n = 77) and DPI (n = 65)), and differential abundance was compared using the Analysis of Compositions of Microbiomes with the Bias Correction (ANCOM-BC) method. Results: No significant difference was observed in α-diversity between the two groups. However, β-diversity analysis revealed significant differences between groups using both Bray–Curtis and weighted UniFrac methods (adjusted p-value = 0.015 and 0.044, respectively). Significant differential abundance between groups, with higher relative abundance in the MDI group compared to the DPI group, was detected at the family level [Carnobacteriaceae (adjusted p = 0.033)] and at the genus level [Granulicatella (adjusted p = 0.021) and Aggregatibacter (adjusted p = 0.011)]. Conclusions: Types of ICS devices are associated with different saliva microbiome compositions in moderate-to-severe pediatric asthma. The causal relation between inhaler types and changes in saliva microbiota composition needs to be further evaluated, as well as whether this leads to different potential adverse effects in terms of occurrence and level of severity. [ABSTRACT FROM AUTHOR] |
|
Copyright of Biomedicines is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder