التفاصيل البيبلوغرافية
| العنوان: |
儿童 IgA 血管炎肾炎伴不同比例新月体形成的 临床和病理特征分析. (Chinese) |
| Alternate Title: |
Clinical and pathological features of children with immunoglobulin A vasculitis with nephritis accompanied by different proportions of crescent formation. (English) |
| المؤلفون: |
白梦刻, 王龙, 李航, 苏杭, 杨月丽, 杨晓青 |
| المصدر: |
Chinese Journal of Contemporary Pediatrics; Dec2024, Vol. 26 Issue 12, p1329-1334, 6p |
| مصطلحات موضوعية: |
BLOOD cell count, ERYTHROCYTES, NEUTROPHIL lymphocyte ratio, BIOMARKERS, GLOMERULAR filtration rate |
| Abstract (English): |
Objective To investigate the impact of the different proportions of crescent formation on clinical manifestations and pathological features in children with immunoglobulin A vasculitis with nephritis (IgAVN). Methods The children with IgAVN were divided into no-crescent group (75 children), ≤25% crescent group (156 children), and >25% crescent group (33 children). Results Compared with the no-crescent group, the other two groups had significant increases in 24-hour urinary protein, urinary immunoglobulin G (IgG)/creatinine ratio, urine red blood cell count, fibrinogen, and neutrophil-lymphocyte ratio, a significant reduction in serum IgG, and a significantly higher proportion of children with low albumin and hypercoagulability, pathological grade III+IV or diffuse mesangial proliferation (P<0.05). Compared with the ≤25% crescent group, the >25% crescent group had significant increases in 24-hour urinary protein, urine red blood cell count, and fibrinogen, significant reductions in serum IgG and glomerular filtration rate, and a significantly higher proportion of children with diffuse mesangial proliferation, tubular atrophy or interstitial fibrosis (P<0.05). Compared with the no-crescent group, the >25% crescent group had significantly higher levels of total cholesterol, triglycerides, urea nitrogen, and serum creatinine (P<0.05). A reduction in serum IgG, hypercoagulability, an increase in 24-hour urinary protein, diffuse mesangial proliferation, and chronic tubulointerstitial lesions were influencing factors for the increase in the proportion of crescent formation (P<0.05). Conclusions For children with IgAVN, the higher proportion of crescent formation is associated with greater abnormalities in laboratory markers and more severe chronic tubulointerstitial lesions, and thus a detailed analysis of the proportion of crescent formation can better guide clinical treatment. [ABSTRACT FROM AUTHOR] |
| Abstract (Chinese): |
探讨IgA 血管炎肾炎（immunoglobulin A vasculitis with nephritis, IgAVN） 患儿不同比例新月体 形成对临床表现和病理特征的影响。方法 按新月体的比例分组并比较, 无新月体组75 例、≤25% 新月体组156 例、>25% 新月体组33 例。结果 与无新月体组比较, 另两组患儿24 h 尿蛋白、尿免疫球蛋白（immunoglobulin G, IgG）/肌酐、尿红细胞、纤维蛋白原、中性粒细胞/淋巴细胞比值升高（P<0.05）, 血清IgG 下降, 出现低白蛋 白状态、高凝状态、病理分级Ⅲ级+Ⅳ级、弥漫性系膜增生占比增高（P<0.05）。与≤25% 新月体组相比, >25% 新月体组24 h 尿蛋白、尿红细胞、纤维蛋白原升高, 血清IgG、肾小球滤过率降低, 弥漫性系膜增生、肾小管萎 缩或间质纤维化占比升高（P<0.05）。>25% 新月体组的总胆固醇、甘油三酯、尿素氮、血肌酐水平高于无新月体 组（P<0.05）。血清IgG 下降、高凝状态、24 h 尿蛋白升高、弥漫性系膜增生和肾小管间质慢性病变是新月体比 例增多的影响因素（P<0.05）。结论 IgAVN 患儿中新月体比例越多, 各项实验室指标异常和肾小管间质慢性病 变更重, 因此细分新月体比例可以更好地指导临床治疗. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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