التفاصيل البيبلوغرافية
| العنوان: |
Quercetin Alleviates Hyperglycemic-Generated Endoplasmic Reticulum Stress-Contacted Apoptosis of Rat Nucleus Pulposus Cells. |
| المؤلفون: |
Zhen Yu, Xianfeng Wang, Yusen Hu, Xinfa Wang, Zhenghuan Zhu, Xu Xu, Yiming Wang, Ailiang Zhang |
| المصدر: |
Balkan Medical Journal; Jan2025, Vol. 42 Issue 1, p27-56, 10p |
| مصطلحات موضوعية: |
BIOLOGICAL models, RESEARCH funding, APOPTOSIS, IN vivo studies, QUERCETIN, HYPERGLYCEMIA, RATS, EXPERIMENTAL design, INTERVERTEBRAL disk, ANIMAL experimentation, ENDOPLASMIC reticulum stress, SPINE diseases, DISEASE complications |
| مستخلص: |
Background: Previous research has shown that apoptosis of nucleus pulposus (NP) cells contributes to intervertebral disc degeneration (IDD) progression. Endoplasmic reticulum (ER) stress is a reaction to diverse stimuli in eukaryotes and is tightly contacted with apoptosis. Quercetin, a naturally occurring flavonoid, exerts protective effects against degenerative diseases via ER stress. However, the effect of quercetin on NP cell apoptosis remains unclear. Aims: To investigate the influences of quercetin on apoptosis and ER stress in a high-glucose-generated primary NP cell model. Study Design: In vivo animal experimental study. Methods: To investigate the influence of quercetin in a high-glucosegenerated NP cell apoptosis model, control, glucose, and glucose + quercetin groups adopted with Sprague-Dawley rats primary NP cells. In the glucose group, cell apoptosis was generated by 200 mm high glucose. In the glucose + quercetin group, 60 µm quercetin was pretreated with NP cells for 2 h before glucose administration. In this research, we examined the change effect of quercetin on NP cell apoptosis, ER stress, and the protein kinase R-like ER kinase (PERK)-eukaryotic translation initiation element 2α (eIF2α)-activating transcription element 4 (ATF4). Results: High glucose decreased the viability and induced ER stressrelated apoptosis in NP cells. Quercetin modulated ER stress through the PERK-eIF2α-ATF4 pathway, thereby alleviating the apoptosis rank in NP cells. Conclusion: Quercetin exerts antiapoptotic effects on NP cells, probably through ER stress, thereby showcasing potential as a therapeutic method for treating IDD. [ABSTRACT FROM AUTHOR] |
|
Copyright of Balkan Medical Journal is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder