التفاصيل البيبلوغرافية
| العنوان: |
Cardiac Urea Cycle Activation by Time‐Restricted Feeding Protects Against Pressure Overload‐Induced Heart Failure. |
| المؤلفون: |
Tan, Yanzhen, Li, Min, Li, Han, Guo, Yongzheng, Zhang, Bing, Wu, Guiling, Li, Jia, Zhang, Qian, Sun, Yang, Gao, Feng, Yi, Wei, Zhang, Xing |
| المصدر: |
Advanced Science; 12/26/2024, Vol. 11 Issue 48, p1-16, 16p |
| مصطلحات موضوعية: |
TRANSCRIPTION factors, HEART beat, HEART failure, AMINO acids, HEART diseases |
| مستخلص: |
Heart failure is a leading cause of mortality worldwide, necessitating the development of novel therapeutic and lifestyle interventions. Recent studies highlight a potential role of time‐restricted feeding (TRF) in the prevention and treatment of cardiac diseases. Here, it is found that TRF protected against heart failure at different stages in mice. Metabolomic profiling revealed that TRF upregulated most circulating amino acids, and amino acid supplementation protected against heart failure. In contrast, TRF showed a mild effect on cardiac amino acid profile, but increased cardiac amino acid utilization and activated the cardiac urea cycle through upregulating argininosuccinate lyase (ASL) expression. Cardiac‐specific ASL knockout abolished the cardioprotective effects afforded by TRF. Circulating amino acids also protected against heart failure through activation of the urea cycle. Additionally, TRF upregulated cardiac ASL expression through transcription factor Yin Yang 1, and urea cycle‐derived NO contributes to TRF‐afforded cardioprotection. Furthermore, arteriovenous gradients of circulating metabolites across the human hearts were measured, and found that amino acid utilization and urea cycle activity were impaired in patients with decreased cardiac function. These results suggest that TRF is a promising intervention for heart failure, and highlight the importance of urea cycle in regulation of cardiac function. [ABSTRACT FROM AUTHOR] |
|
Copyright of Advanced Science is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder