التفاصيل البيبلوغرافية
| العنوان: |
Factors impeding organ recovery despite a deep haematological response in patients with systemic AL amyloidosis. |
| المؤلفون: |
Staron, Andrew, Mendelson, Lisa M., Joshi, Tracy, Burke, Natasha, Sanchorawala, Vaishali |
| المصدر: |
British Journal of Haematology; Dec2024, Vol. 205 Issue 6, p2268-2272, 5p |
| مصطلحات موضوعية: |
AMYLOIDOSIS, KIDNEYS, LIVER, HEART, DIAGNOSIS |
| مستخلص: |
Summary: Patients with AL amyloidosis can have persistent organ dysfunction despite achieving a haematological complete response (hemCR). We aimed to identify factors for organ non‐response among 143 patients who achieved hemCR for ≥6 months. Kidney, heart and liver non‐response were observed in 40/117 (34%), 19/68 (28%) and 3/17 (18%) patients respectively. Predisposing factors varied by organ system. Kidney non‐responders had more advanced organ dysfunction at diagnosis, whereas heart non‐responders had disproportionately more lambda‐typic amyloidogenic light chains. Most patients without an apparent reason for organ non‐response had detectable residual clonal disease. The interplay of factors impeding organ recovery in AL amyloidosis is complex. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |