التفاصيل البيبلوغرافية
| العنوان: |
A shift in chromatin binding of phosphorylated p38 precedes transcriptional changes upon oxidative stress. |
| المؤلفون: |
Camilleri‐Robles, Carlos, Climent‐Cantó, Paula, Llorens‐Giralt, Palmira, Klein, Cecilia C., Serras, Florenci, Corominas, Montserrat |
| المصدر: |
FEBS Letters; Dec2024, Vol. 598 Issue 23, p2926-2938, 13p |
| مصطلحات موضوعية: |
GENETIC transcription, GENE expression, PROTEIN kinases, REACTIVE oxygen species, GENETIC translation |
| مستخلص: |
P38 mitogen‐activated protein kinases are key in the regulation of the cellular response to stressors. P38 is known to regulate transcription, mRNA processing, stability, and translation. The transcriptional changes mediated by phosphorylated p38 (P‐p38) in response to extracellular stimuli have been thoroughly analyzed in many tissues and organisms. However, the genomic localization of chromatin‐associated P‐p38 remains poorly understood. Here, we analyze the chromatin binding of activated P‐p38 and its role in the response to reactive oxygen species (ROS) in Drosophila S2 cells. We found that P‐p38 is already bound to chromatin in basal conditions. After ROS exposure, chromatin‐associated P‐p38 relocates towards genes involved in the recovery process. Our findings highlight the role of P‐p38 dynamic chromatin binding in orchestrating gene expression responses to oxidative stress. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |