التفاصيل البيبلوغرافية
| العنوان: |
Immunogenicity and safety of ebolavirus vaccines in healthy adults: a systematic review and meta-analysis of randomized controlled trials. |
| المؤلفون: |
Yin, Juntao, Zhang, Liang, Wang, Chaoyang, Qin, Changjiang, Miao, Mingsan |
| المصدر: |
Expert Review of Vaccines; Jan-Dec2024, Vol. 23 Issue 1, p148-159, 12p |
| مصطلحات موضوعية: |
EBOLA virus, HEALTH policy, RANDOMIZED controlled trials, VIRAL vaccines, IMMUNE response |
| مستخلص: |
Background: This review aimed to systematically evaluate the immunogenicity and safety of the candidate Ebola virus vaccine (EVV). Methods: We searched five databases for randomized controlled trials (RCTs) evaluating the effects of EVV on healthy adults. The primary outcomes were relative risk (RR) of sero-conversion or sero-response of EVV in healthy adults between the groups that received EVV and the controls. Results: Twenty-nine RCTs (n = 23573) were included. There was a significant difference in RR of sero-conversion of EVV (RR 13.18; 95% CI 11.28–15.41; I2 = 33%; P < 0.01) between the two groups. There was a significant difference in RR of adverse events (AEs) of EVV (RR 1.49; 95% CI 1.27–1.74; I2 = 88%; P < 0.01), although no difference in RR of serious AE (SAE) between the two groups. Subgroup analysis showed that there was no significant difference in RR of AEs for DNAEBO, EBOV-GP, MVA, and rVSVN4CT1 vaccines, compared with controls. Conclusions: The DNAEBO, EBOV-GP, MVA, and rVSVN4CT1 vaccines are likely to be safe and immunogenic, tending to support the vaccination against Ebola disease. These findings should provide much-needed evidence for public health policy makers to develop preventive measures based on disease prevalence features and socio-economic conditions. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |