التفاصيل البيبلوغرافية
| العنوان: |
Monoclonal Gammopathy in Patients with Neuropathy. |
| المؤلفون: |
Ji Yeon Ham, Jae Hee Lee, Nan Young Lee, Kyung Eun Song |
| المصدر: |
Clinical Laboratory; 2024, Vol. 70 Issue 11, p2132-2136, 5p |
| مصطلحات موضوعية: |
IMMUNOGLOBULIN light chains, IMMUNOGLOBULIN M, ANTINEUTROPHIL cytoplasmic antibodies, BLOOD protein electrophoresis, ANTICARDIOLIPIN antibodies, ANTINUCLEAR factors |
| مستخلص: |
Background: The incidence of monoclonal gammopathy of undetermined significance (MGUS) in the population of over 50-year-olds is approximately 3% and increases with age. The association between MG and neuropathy has been of interest for several years, but the causal relationship has not yet been clarified. Methods: For 682 patients who visited the Department of Neurology and requested tests for MG work-up, we retrospectively collected demographic and clinical information, such as age, gender, diagnosis, and neurologic and laboratory test results, from their medical records. Results: Out of a total of 682 patients who were suspected of neuropathy and tested for monoclonal gammopathy (MG), twelve (1.76%) showed MG on their serum protein electrophoresis. The most common form was IgM-κ with five patients, followed by IgG-κ, IgG-λ, and biclonal IgG-λ and IgA-κ. The results of the immunoglobulin quantitation test and free light chain assay showed that involved M-protein values in these patients were increased. Some patients were positive for anti-myelin-associated glycoprotein (MAG) antibody, anti-GD1b IgM antibody, anti-GM1 IgG & IgM antibody, and anti-cardiolipin IgM antibody. Also, some had antinuclear antibody (ANA) or antineutrophil cytoplasmic antibody (ANCA). Conclusions: In the future, it is necessary to investigate the pathogenic relationship between M-protein and autoantibodies in patients with neuropathies. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |