التفاصيل البيبلوغرافية
| العنوان: |
Terahertz spectroscopy study of oridonin and ponicidin in the anticancer Chinese herbal medicine Rabdosia rubescens. |
| المؤلفون: |
Gao, Yang, Peng, Zhuang, Yang, Huiyu, Zhang, Xinrui, Zhao, Yuhan, Hou, Zeyu, Su, Bo, Li, Kai, Zhang, Cunlin |
| المصدر: |
Frontiers in Plant Science; 2024, p1-11, 11p |
| مصطلحات موضوعية: |
TERAHERTZ time-domain spectroscopy, MOLECULAR vibration, MOLECULAR structure, MOLECULAR spectra, HERBAL medicine, TERAHERTZ technology |
| مستخلص: |
Rabdosia rubescens, a Chinese herbal medicine with anticancer properties, contains two active ingredients: oridonin and ponicidin. Both compounds exhibit antitumor effects by inducing tumor cell apoptosis and autophagy and inhibiting tumor cell proliferation. To further explore the differences in molecular structure and pharmacological properties between the two substances, this study employs Terahertz Time-Domain Spectroscopy (THz-TDS) to investigate the spectral characteristics of oridonin and ponicidin in the frequency range of 0.1 to 2.3 THz. The crystal structures of the two substances are simulated using Materials Studio software and Density Functional Theory (DFT), yielding their spectra and molecular vibration modes, which elucidate the mechanism underlying the peak generation. The consistency between experimental and simulation results confirms the reliability of the experimental findings. Thus, THz spectroscopy can effectively distinguish between these two substances. Finally, a THz detection is performed on Rabdosia rubescens capsules purchased from the market, revealing the presence of absorption peaks for both substances in their absorption spectra. This provides a new approach for detecting active ingredients in Chinese herbal medicines. [ABSTRACT FROM AUTHOR] |
|
Copyright of Frontiers in Plant Science is the property of Frontiers Media S.A. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder