التفاصيل البيبلوغرافية
| العنوان: |
Activation of platelets and the complement system in mice with Schistosoma-induced pulmonary hypertension. |
| المؤلفون: |
Mickael, Claudia, Jordan, Mariah, Posey, Janelle N., Tuder, Rubin M., Nozik, Eva S., Thurman, Joshua M., Stenmark, Kurt R., Graham, Brian B., Delaney, Cassidy A. |
| المصدر: |
American Journal of Physiology: Lung Cellular & Molecular Physiology; Nov2024, Vol. 327 Issue 5, pL661-L668, 8p |
| مصطلحات موضوعية: |
BLOOD platelet activation, COMPLEMENT activation, PULMONARY hypertension, PROTEIN receptors, SCHISTOSOMA, COMPLEMENT receptors |
| مستخلص: |
Schistosomiasis-induced pulmonary hypertension (PH) presents a significant global health burden, yet the underlying mechanisms remain poorly understood. Here, we investigate the involvement of platelets and the complement system in the initiation events leading to Schistosoma-induced PH. We demonstrate that Schistosoma exposure leads to thrombocytopenia, platelet accumulation in the lung, and platelet activation. In addition, we observed increased plasma complement anaphylatoxins C3a and C5a, indicative of complement system activation, and elevated platelet expression of C1q, C3, decay activating factor (DAF), and complement C3a and C5a receptors. Our findings suggest the active involvement of platelets in responding to complement system signals induced by Schistosoma exposure and form the basis for future mechanistic studies on how complement may regulate platelet activation and promote the development of Schistosoma-induced PH. NEW & NOTEWORTHY: Schistosomiasis-induced pulmonary hypertension (PH) is a significant global health burden, yet the underlying mechanisms remain poorly understood. We demonstrate that Schistosoma exposure leads to platelet accumulation in the lung and platelet activation. We observed increased plasma levels of C3a and C5a, indicative of complement system activation, and elevated expression of platelet complement proteins and receptors. These findings underscore the role of platelets and complement in the inflammatory responses associated with Schistosoma-induced PH. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |