التفاصيل البيبلوغرافية
| العنوان: |
NANOFIBER ENCAPSULATION: REVOLUTIONIZING BIOPHARMACEUTICAL DELIVERY THROUGH ELECTROSPINNING. |
| المؤلفون: |
Mehta, Farhad F., Thulasimani, T., Raziya, Sk., Chakraborthy, Gunosindhu, Dewan, Shailee, Behera, Snigdha Rani, Mishra, Avinash Kumar Vivekanand, Babu, Bonige Kishore |
| المصدر: |
Biochemical & Cellular Archives; Oct2024, Vol. 24 Issue 2, p2747-2760, 14p |
| مصطلحات موضوعية: |
DRUG bioavailability, ELECTROSPINNING, SMART materials, SMALL molecules, PROCESS optimization |
| مستخلص: |
Nanofiber encapsulation represents a groundbreaking approach in the realm of biopharmaceutical delivery, leveraging the versatility of electrospinning technology to enhance the therapeutic efficacy and stability of bioactive agents. This review explores the fundamental principles and advantages of electrospun nanofibers, which provide a high surface-area-to-volume ratio, tunable porosity and the ability to incorporate a wide range of biopharmaceuticals, including proteins, peptides, nucleotides and small molecules. The encapsulation process facilitates controlled release profiles, improving drug bioavailability and minimizing side effects. Furthermore, the unique structural properties of nanofibers enable targeted delivery, enhancing drug localization at disease sites while reducing systemic exposure. We discuss recent advancements in material selection, process optimization, and formulation strategies that contribute to the development of nanofiber-based delivery systems. Challenges such as scalability, regulatory considerations and the reproducibility of electrospinning processes are also addressed. This review underscores the potential of nanofiber encapsulation to revolutionize biopharmaceutical delivery systems, paving the way for novel therapeutic modalities and improved patient outcomes. Future research directions emphasize the integration of smart materials and advanced characterization techniques to further enhance the performance of electrospun nanofiber platforms in the biopharmaceutical landscape. [ABSTRACT FROM AUTHOR] |
|
Copyright of Biochemical & Cellular Archives is the property of Dr. P.R. Yadav and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |